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A transient breach in the epithelial barrier leads to the resistance to colitis This study was the first direct attempt to understand how physiologic breaks in the mucosal barrier, which must occur for homeostatic regulatory T cells to develop (Figure 1), may differ from the pathological mucosal barrier defects widely implicated in promoting inflammation of the underlying lamina propria

You may have a deficiency if you are vegan, dont eat enough B12 rich food, or if you have other health conditions which mean you are unable to absorb it properly, such as pernicious anaemia

Consistent resistance training, sleep hygiene seriously maintained, and nutrition optimized to a degree that most clinical nutritionists would consider aggressive

Think of it like filling a bathtub with the drain partially open