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Additional studies have shown that LacCer activates cytosolic phospholipase A2 (PLA2) and MAV2 in astrocytes and that, autocrinely, this pathway leads to NFkB activation and transcription of inflammatory factors, contributing to the pathogenesis of EAE and MS

showed that in a necrotizing enterocolitis (NEC) mouse model and IEC-6 cells, CCL3 upregulation exacerbated intestinal damage by promoting apoptosis through the CCL3CCR4ERK1/2NFBBAX/BCL-2 axis (Yuan et al., 2022)

Our glutathione is a highly potent agent that is manufactured to the strictest specifications

Similar content being viewed by others Background Christian de Duve, a Nobel Prize winner in 1974, observed cellular autophagic structures by electron microscopy sixty years ago due to the discovery of peroxisomes and lysosomes [1, 2]