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doi: 10.1186/s40779-020-00240-0 45 HaickA
The researchers found that 0404 operated through a positive feedback loop involving the p53/miR-34a/SIRT1 pathway to induce cell apoptosis at a nanomolar concentration
This hypothesis states that cell death in nigral neurons is caused by an interaction between environmental conditions and genetic predisposition, resulting in mitochondrial respiratory failure and oxidative stress [3]
2013 (7) CD007168
