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Hematologic changes and serum B12 rise over weeks to months
In the presence of inflammatory signals, neutrophils first infiltrate into the sites of infection, injury, or inflammation

J Clin Invest 125: 22932306 Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL (2012) Inhibition of alphaKGdependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

doi: 10.1172/JCI84427 80 CopelandBTShallalHShenCPientaKJFossCAPomperMG
