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SIRT1 deacetylates target proteins by hydrolyzing NAD + and simultaneously transferring the lysine-bound acetyl group from acetylated proteins to the 2-OH position of ADP-ribose, ultimately yielding nicotinamide and 2-O-acetyl-ADP-ribose ( Figure 1 ) ( + dependence determines that the levels of NAD + and SIRT1 activity are tightly coupled

By protecting immune cells from oxidative damage, glutathione supports their optimal function and enhances immune responsiveness
