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Despite a clear role of serotonin decreasing uterine and placental vascular perfusion by promoting vasoconstriction of uterine/placental vascular beds 4,45,46,47 , decreased estrogen may also be involved in the decreased perfusion and growth of the placenta as estradiol regulates uteroplacental angiogenesis, endothelial cell proliferation, and vasodilation through genomic and nongenomic pathways 48,49,50

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Due to this, citric acid is usually included in small amounts as a pH adjuster

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