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The histological and ultrastructural findings are identical to those of the CaLS, and so some authors propose to include freckles and CaLS in the same diagnostic criterion.41 We also support this proposal, particularly if we remember that Legius syndrome meets 2 criteria in 48% of cases and presence of both criteria does not increase the specificity of diagnosis.24 Freckles can appear in other genetic diseases included in the differential diagnosis (Table 2), particularly in cases in which they coexist with CaLS

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Differentiation potential of synovial mesenchymal stem cells isolated from HIP joints affected by femoroacetabular impingement syndrome versus osteoarthritis