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Autoimmune encephalitis (where symptoms include psychiatric features, confusion, memory loss and seizures followed by a movement disorder, loss of consciousness and autonomic fluctuations) and related disorders have also been associated with anti GABA-B receptor antibodies and/or glutamic acid decarboxylase (GAD the enzyme responsible for converting glutamic acid to GABA) antibodies (Boronat et al, 2011)

A very important consequence of the slightly alkaline pH is the fact that the NADH/NAD + redox pair can be brought in redox equilibrium with the GSH redox pair GSH/GSSG

Future studies will be necessary to clarify whether and how LDHB contributes to ferroptosis surveillance in KRAS -mutant cancer harboring wildtype KEAP1 and expressing low levels of NRF2

Mittermaier M, Venkatesh KP, Kvedar JC