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Hesperidin has poor solubility and faces obstacles to its absorption in the gastrointestinal tract [198,199]

Mast cell-derived mediators, including leukotrienes (LTs), histamine, and interleukins, contribute to bronchoconstriction, airway inflammation, and structural remodeling across different asthma endotypes

doi: 10.1159/000493390 9 SparksJA
