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Through a combination of in vitro biochemistry, in vivo metabolomics, and culture experiments, we now unambiguously resolve Rv3722c as the primary AspAT of Mtb , Rv0337c as an alanine transaminase and Rv3565 as an alaninevaline transaminase, further analyses of which may improve future sequence-based predictions

Methylation of DNA not only serves to control gene expression i, but also provides a mechanism through which environmental factors can have long-lasting effects on the genome