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Epicatechin intake can enhance Nrf2 and heme oxygenase-1 (HO1) protein levels in the nuclei of cortical neurons in mice (Wu et al., 2006), and activate the phosphatidylinositol-3-kinase/protein kinase B (PI3K)/AKT and extracellular-regulated kinase (ERK) signaling pathways in hepatocytes (Si and Liu, 2014)
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