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Actually, serum level of methionine is dramatically increased in LIHC patients compared with healthy subjects [110, 111], and mice lacking Mat1a have reduced hepatic SAM levels and developed oxidative stress, steatohepatitis, and hepatocellular carcinoma [112]

Table 1 Baseline characteristics of MM patients

The stimulation of hypothalamic POMC neurons is inhibited by -endorphin as an opioid reward process is involved in the short-term control of eating [239]

Immediately following injury (days 1 and 2), there was a more pro-inflammatory environment, as evident by the abundance of Ccr2 + monocytes/macrophages
