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The value of this variable, called Z B , can be calculated for each titration point according to Equation (1): (1) In Equation (1), H is the total concentration of protons in the solution (calculated according to Equation (2) below), h is the free concentration of protons in the solution (calculated according to Equation (3) below), [OH ] is the concentration of hydroxide ions in solution and B is the total concentration of DHBA in the solution (calculated according to Equation (4) below)

Kim et al., 2008) (Figure 1)

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We propose the lactateNAMPT axis as a framework to delineate this complexity