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Systemic reactions may include gastrointestinal disturbances (nausea, diarrhea, abdominal cramps) when large doses are administered intravenously

On this basis, the presence of microvascular alterations in a pre-diabetic mouse model also suggests that early hyperinsulinaemia and insulin resistance are sufficient to induce vascular damage and that bloodbrain barrier dysfunction precedes cognitive decline (25)

Enhancing interpretability and accuracy of AI models in healthcare: a comprehensive review on challenges and future directions

Aspirin has also been shown to protect against acetaminophen-induced liver toxicity due to down regulation of proinflammatory cytokines rather than COX-1 inhibition [15]