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Choice A: A population bottleneck describes a sharp reduction in population size due to environmental events, leading to decreased genetic diversity

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The metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), which selectively bind VMAT2, inhibit monoamine transport, and deplete dopamine and other neurotransmitters in the CNS, are produced quickly by carbonyl reductase from both tetrabenazine and deutetrabenazine

injection (which by definition produces 100% bioavailability)