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A coffee enema rather than an oral dose was utilized in this study because 1 L of coffee extract is difficult to ingest in addition to the customary 2 L of PEG, and the coffee solution itself could impede VCE

doi:10.1016/S0022-5347(17)49698-4

This site was very highly scored by PROSPER, as well as Procleave, despite the glutamine (Q) at P1, which has an additional carbon atom relative to the asparagine (N) found at P1 in the nsp8/9 site, to which it is otherwise most similar

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