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22 Altogether, the clinical consequences for patients with loss of ISC biosynthetic proteins can vary widely, either because of the precise ISC containing proteins affected, the way in which ISC biogenesis is affected, or because ISC formation and stability are highly dependent on the cell type and local environment, particularly environmental oxygen concentration

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10.1161/ATVBAHA.109.193375 [DOI] [PubMed] [Google Scholar] 238.Fiorelli S, Porro B, Cosentino N, Di Minno A, Manega CM, Fabbiocchi F, et al

[] Incidence rates of PCa vary geographically, with lower rates observed in developing countries in South and East Asia, and higher rates recorded in developed countries, such as North America, Europe, Australia, and New Zealand