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MATERIALS AND METHODS Animals Male Albino Wistar (350-400 g) rats, were used in all of the experiments (10 rats at least per each experimental group and interval randomly assigned) approved by the Local Ethic Committee and assessed by observers unaware of the given treatment

doi: 10.3389/fncel.2021.673217 356 CostaDCTannockCBrostoffJ

Overall, the increased plasma volume and lower ratio of lean muscle to adipose tissue during pregnancy and lactation can result in changes in the volume of drug distribution for drugs, including alcohol
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