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No PCT is required as 5-Amino-1MQ does not affect hormonal pathways

Whether this observation is solely the consequence of translocation of Parasutterella bacteria from the intestine to the EWAT or driven by more indirect mechanisms such as bacterially-produced metabolites 85 is yet to be determined

The treatment group showed significant reductions in body weight (approximately 5% loss) and white adipose tissue mass (35% reduction) compared to control animals, despite no changes in food intake

Demonstrates that NNMT activity regulates adipogenesis and energy expenditure in murine models, establishing NNMT as a key metabolic enzyme target