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Inactivation of PTEN activates Akt and -catenin [102]

Additionally, the oral bioavailability observed in animal models makes the compound attractive for potential clinical development

While GASP1 was shown to more potently bind MSTN/GDF11 than GASP2 in vitro 29 , GASP2 was shown to more specifically regulate GDF11 based on the similarity of the embryonic expression patterns of Gasp2 and Gdf11 and the phenotype of Gasp2 knockout mice, which exhibited posterior homeotic transformations indicative of GDF11 overactivity 30

As fat tissue increases, more hormones and inflammatory properties are produced, resulting in a snowball effect of weight gain and often health-related problems associated with it