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5.4 Regulation of mitochondrial dysfunction Mitochondria, as subcellular organelles containing DNA, provide energy to cells through oxidative phosphorylation (Antolnez-Fernndez et al., 2024) and are implicated in various pathophysiological processes in VaD

J.HadidiM.VarchehM.JelyaniA

That approach improves interpretability, reduces unnecessary escalation, and keeps the work anchored in a research-only context where safety controls and documentation are part of the protocol, not an afterthought

Excessive mitophagy leads to the removal of large numbers of mitochondria, resulting in the release of large amounts of iron, ROS, and lipid peroxidation from the mitochondria, which activates multiple ROS-induced cell death pathways, including ferroptosis [54, 55]
