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Description
PNPLA2 has retinyl esterase activity, which is activated by ABHD5 in hepatic stellate cells (78)

It does not increase growth hormone levels
K.H.P., L.B.V., E.L.: Formal analysis

Tirzepatides glucagon-receptor occupancy stays under 0.3% even at 15 mg. So its liver-fat reduction, its lipid improvements, and its heart-rate rise do not run through a glucagon arm the way retatrutides do
