bpc-157 fibrosis risk Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia–Reperfusion Injury BPC-157 as an Investigational Peptide

The 2009 Watson et al

(4) The researchers reported, On days 6, 10, and 13, tripeptide-copper complex-treated wounds contained significantly lower concentrations of TNF-alpha and MMP-2 and MMP-9 than control wounds. Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

We showed that it was effective and that it was a local effect within the kidney itself. Current therapies, like corticoid steroids, generally suppress the immune response, leaving patients at risk for infection and even cancer

The lower bioavailability of the oral route compared to intravenous injection is explained in the figure below (Oral vs