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This is why, for example, short-acting benzodiazepines such as alprazolam and lorazepam are more difficult to discontinue than long-acting benzodiazepines such as diazepam and clonazepam

Role of Nrf2 and PPAR-

Through pharmacokinetic analysis of brain tissue, they found that the nanocarrier increased the amount of puerarin in the brain only 6.46-fold, although blood pharmacokinetic analysis revealed a more significant improvement in the systemic circulation of puerarin (tenfold), indicating that the efficiency of delivery to the brain was lower in the nanomedicine group than in the free drug group

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