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Structure assignment revealed several key metabolic sites and diverse biotransformation pathways, including ester hydrolysis, aldehyde reduction, aldehyde oxidation, hydroxylation (monohydroxylation and dihydroxylation), glucuronidation, and the cross-combination of these pathways
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For example, surveys and claims-data show that atorvastatin (a cholesterol-lowering statin) and amlodipine (a blood-pressure calcium-blocker) were the #1 and #2 most prescribed drugs by claims in 2025
