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In contrast, a significant difference was found between cases and controls in the SOD2 Ala 16 Val (C/T) (Harris, 2017) polymorphism (CC versus TT: OR = 2.158, p = 0.038)

Useful indication Researchers are also recognising that elevated B12 may not be a cause of cancer, but it could be a useful marker of whether cancer is present or progressing

Safety, trade-offs and trial design Avoid trading one pathology for another: excessive suppression of ROS can blunt host defense, neuroplasticity and adaptive stress responses, whereas excessive amplification can select resistant cancer clones or precipitate ferroptosis in vulnerable, PUFA-rich tissuesso aim for balance, not extremes (Kakizawa et al

Furthermore, a possible role of glial cell line-derived neurotrophic factor (GDNF) for predicting CI in PD has been suggested, which, however, awaits confirmation (Shi et al., 2021)