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The HepDirect prodrug strategy has also been employed for a thyroid receptor agonist in order to lower cholesterol by increasing oral bioavailability in rats 40-fold [57,58] and as a means to overcome inhibition of CYP3A4 in a molecule targeting glucose production seen with the use of other pro-moieties [59]
Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats
