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By using knockouts, applying reaction precursors and using inducible genetics, the relative contributions of various steps in a pathway can now be quantified

The immediate consequence of this E/I imbalance is neuronal hyperexcitabilityan increase in spontaneous firing rates (SFRs) and bursting activity in AC neurons, which directly correlates with tinnitus behavior (Cai et al., 2024)

doi: 10.3389/fpls.2025.1597007

Ito cells (stellate cells) are peri-sinusoidal cells that store vitamin A and are also a major source of collagen in the liver
