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At the molecular level, hepatic Gclc or Gclm KO triggers a robust activation of Nrf2 and its target genes in liver (12, 13), indicating increased oxidative stress response, whereas Nrf2 level is not increased in livers with Chac1 overexpression

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Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinsons Disease