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Thus, energy deficiency, depleted levels of energy substrates, and glutathione depletion are widespread systemic features of AKI

The underlying relationship between high -PL production, biomass, mycelial viability, ATP accumulation, and pH shock was further explained by transcriptomic profiling at the early, middle, and late stages of -PL fermentation, which showed up-regulation of transcriptional regulatory genes involved in nitrogen metabolism, energy metabolism, electron respiratory chain, and redox homeostasis (Pan et al., 2019a)
