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The mammalian fetus of all species appears to be capable of degrading heme without limitation, through the two enzymatic steps responsible for the formation of unconjugated bilirubin IX-, HO and biliverdin (see Figure 100-2)
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To investigate the underlying mechanism of KCNN3 in HCC, we identified the interaction between the E3 ubiquitin ligase connector SPOP protein and KCNN3 through mass spectrometry analysis, CO-IP, GST pull-down and IF experiments
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