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Rhabdomyolysis, neuropathy and coagulopathy may occur and should be treated appropriately

It allows for the analysis of coordinated modulation of nitric oxide signaling, cytokine production, extracellular matrix remodeling, and pathways related to progenitor cells

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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation