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Mutant SOD1 G93A and SOD1 G85R activate microglia and increase the levels of ROS and other pro-inflammatory cytokines (Zhao et al., 2010)
doi: 10.1021/acs.jmedchem.0c01163 [DOI] [PubMed] [Google Scholar] 365

Phase 2 dose-finding trial Published in The Lancet in 2021, this multicenter, randomized, double-blind trial tested cagrilintide doses ranging from 0.3 mg to 4.5 mg weekly in people with overweight or obesity

Lactoferrin is important for the immune system