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Ben Zhou, Dr

283 Mitochondria in aging and oxidative stress Harman proposed the free radical theory of aging in the 1950s, which hypothesized that the increase of free radicals, especially oxygen free radicals, would induce oxidative stress, causing damage to a variety of bioactive substances and accelerating aging

10.1001/jamaneurol.2015.0613 JAMA Neurol

Meanwhile, although we have excluded the DM patients with comorbidity bipolar disorder, depression, psychosis et al., adequate bias control was still lacking