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Current treatments for GBM remain palliative rather than curative
The UPS is the primary intracellular non-lysosomal pathway for protein degradation, consisting of substrates, ubiquitin molecules, ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), ubiquitin-ligase enzymes (E3), 26S proteasomes, and deubiquitinating enzymes (DUBs) 15,19,20,21

Comparing the effectiveness of dietary vitamin C and exercise interventions on fertility parameters in normal obese men

PGC-1alpha, a key modulator of p53, promotes cell survival upon metabolic stress
