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Practical Interpretation The mechanistic plausibility (NNMT NAD SIRT1/PGC-1 BMR & fat oxidation) is strong and consistent across preclinical models
Its mechanism restoring NAD+ availability and reactivating SIRT1-mediated pathways directly addresses mitochondrial dysfunction, impaired glucose tolerance, and hepatic steatosis, all hallmarks of metabolic syndrome
A B12 overdose might trigger nausea or diarrhea
