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Collectively, they suggest four principal ways through which CS imposes ROS burden on biological systems: (1) ROS, as well as radicals, are intrinsically present in CS, (2) CS constituents can induce ROS generation via chemical reactions with biomolecules, (3) CS can stimulate endogenous ROS sources in cells to produce ROS, and (4) CS can interfere with antioxidant systems, thereby exacerbating the production or functions of ROS (Figure 1)
What to avoid: Alcohol, certain pain relievers such as NSAIDs and aspirin, high-dose turmeric supplements, and heavily processed foods may worsen low platelet counts or affect clotting

107 A randomized controlled trial included 102 tinnitus patients who received either melatonin (3 mg nightly) plus sulodexide, melatonin (3 mg nightly) alone, or no treatment for 80 days