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The most common cause of chronic low-back pain is the deterioration of discs between the vertebrae

The mitochondrial translocation of phospho-JNK causes the enhanced leakage of electrons from the electron transport chain and formation of superoxide, which reacts with nitric oxide (NO) to form the highly reactive oxidant peroxynitrite in the mitochondria [49]

Values represent means SEM ( n = 1116/genotype/diet)

COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-B signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with giardia duodenalis