hutchinsons melanotic freckle prognosis Lentigo maligna and lentigo maligna melanoma Lentigo maligna part I: Epidemiology,

158 XuS.PiH.ZhangL.ZhangN.LiY.ZhangH.et al (2016)

Lp-PLA 2 can also hydrolyze long chain fatty acyl phospholipid hydroperoxides, phospholipids containing isoprostanes esterified at the sn -2 position and other lipid esters such as short-chain diglycerides, triglycerides, and acetylated alkanols

Though the group reported appreciable 1000:1 selectivity for hMC4R affinity compared to hMC1R affinity, functional cAMP assay results were only reported for hMC4R (EC 50 = 88 nM, E max = 85%), seen in Table 1 ( 50 = 31 nM, E max = 105%) but only had partial agonist activity at hMC3R (EC 50 = 39 nM, E max = 31%) ( Conde-Frieboes et al

In total, 88 tumour samples from 13 patients were analysed