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The increased amount of GABA then downregulates the GABA receptors, making the net effect less of an inhibitory signal.[ref] GABA can also be metabolized into creatine, and an increase in both GABA and creatine is found in people with dysfunction in the ALDH5A1 gene
Akyuva et al
Nozohouri S, Salehi R, Ghanbarzadeh S, Adibkia K, Hamishehkar H
