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Cholesterol homeostasis affects brain health In the brain, cholesterol is necessary for synaptogenesis, neuronal differentiation and plasticity, regeneration and myelinization, and normal neuronal function and morphology (Hussain et al., 2019)

Chronic GSH deficiency by Gclm deletion in mice has also been associated with metabolic alterations and the activation of the stress-responsive factor AMPK 53,84

9 into a hierarchical heatmap, using Log2 values of normalized gene expression levels

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