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If you're in UK, I recommend reading all these documents below UK B12 documents BSH Cobalamin and Folate Guidelines b-s-h.org.uk/guidelines/gui
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Potential Benefits Substantial weight loss: Around 20% body-weight reduction by 72 weeks on the 15 mg dose [2]
However, the 5.2% weight loss effect of setmelanotide in patients with BBS aged 12 years and older