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Nat Genet 35:341348 Taubert D, Grimberg G, Jung N, Rubbert A, Schmig E (2005) Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohns disease

They act as metabolic thermostats, upregulating cellular energy production when the body is depleted and downregulating hyperactive stress responses when the nervous system is overwhelmed

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this was found to have a significant effect on progression to requiring treatment in early PD
