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Description
Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage
During the promotion stage, cells undergo identical mutations due to the stimulation of cell growth and/or suppression of apoptosis [37]
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