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Formation of GSH from -glutamylcysteine catalyzed by glutathione synthetase) ( Figure 1 ) ( de novo via a trans-sulfuration pathway in some tissues (for example, liver, kidney, and pancreas), however, SLC7A11 remains an important transporter for cancer cells that are largely dependent on extracellular cystine for survival ( Slc7a11 knockout mice are viable, fertile, healthy in appearance with no evident deleterious phenotype, and live a normal lifespan ( de novo synthesis of cysteine and/or its import via transporters other than SLC7A11 can fulfill the requirement of intracellular cysteine in normal cells or tissues in the absence of SLC7A11

Microglial function in the effects of early-life stress on brain and behavioral development

Changes in Male rat sexual behavior and brain activity revealed by functional magnetic resonance imaging in response to chronic mild stress

Another compound, HPP971, elevated reduced GSH levels and protected human astrocytes from H 2 O 2 -induced cell death in vitro and induced HO1 expression in a murine EAE model of MS, attenuating loss of motor functions [304]