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Chronic ethanol intake also suppresses the activity of peroxisome proliferator-activated receptor-alpha (PPAR), which is a nuclear hormone receptor that upregulates the expression of many genes involved in the transport and beta-oxidation of free fatty acids (FFAs), including the gene encoding carnitine palmitoyltransferase 1 (CPT1) in mitochondria (Zhang et al., 2018a)
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