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The oxime group in the structure of FIN56 is essential for the induction of ferroptosis, and the hydrophobicity of the piperidine group affects the potential of ferroptosis

Additionally, we discuss recent advancements in understanding metallodrugs mechanisms, such as protein interactions, enzyme inhibition, DNA interactions, reactive oxygen species (ROS) generation, and cellular structure targeting

GH treated-breast cancer cells MDA-MB-435S, T47D, and endometrial cancer cell RL95-2 show significantly reduced DNA damage and heightened clonogenic survival post-irradiation (Wu et al., 2014)

van den Heuvel SAS, van der Wal SEI, Smedes LA, Radema SA, van Alfen N, Vissers KCP, et al