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Collectively, these advances shift the focus from BBB penetration alone to a holistic framework linking transport, distribution, pharmacodynamics, and safety

[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Shin MS, Park SS, Lee JM, Kim TW, Kim YP

FIGURE 2 Mechanical stress induced by increased IOP in glaucoma results in increased EGF receptor expression following astrocyte activation, as well as increased levels of TNF-, matrix metalloproteinases (MMPs), endothelins, and nitric oxide synthase 2 (NOS-2), ultimately leading to a neurodegenerative response (Liddelow et al., 2017