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3.3 Challenges in predicting clinical outcomes Discrepancies between preclinical and clinical outcomes remain a persistent challenge in mitochondrial research, driven by differences between model systems and human pathophysiology

A minimal physiologically based pharmacokinetic model for high-dose methotrexate

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Introduction The liver is a major site of metabolism and detoxification of drugs and xenobiotics in the human body ( CYP2E1 ) increases, with an increase in the formation of a highly reactive toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI) (Wang et al., 2017)