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235, 236 In addition, a decrease in the sensitivity of cancer cells to the cytostatic/cytotoxic effects of CDDP has been associated with the upregulation of microRNAs that target the major oncosuppressive factor phosphatase and tensin homolog (PTEN), such as miR-130a and miR-93, 240, 241 and ERCC1, like miR-138, 237 as well as with the downregulation of microRNAs that normally limit the expression of cell cycle-associated proteins such as let-7b

The clinical complications are varied and may present at any time in the patient's life, mainly the neurological symptoms

[DOI] [PMC free article] [PubMed] [Google Scholar] 138.Zhang R, Xu L, Zhang D, Hu B, Luo Q, Han D, et al

DOI 10.3843/GLOWM.417703 The Continuous Textbook of Womens Medicine Series Gynecology Module Volume 3 Endometriosis Volume Editors: Professor Andrew Horne , University of Edinburgh, UK Dr Lucy Whitaker , University of Edinburgh, UK Chapter First published: November 2023 AUTHOR(S) Robinson Research Institute and Adelaide Medical School, The University of Adelaide, SA, Australia